Science Daily (Oct. 21, 2008) — A recently identified cancer-causing protein makes the anti-leukemia drug imatinib, less effective. By blocking the protein, an international team of researchers was able to slow the spread of leukemia cells in culture.

The study, which will appear online on October 20 in the Journal of Experimental Medicine, suggests that the most effective treatment for leukemia may rely on a combination of targeted drugs, rather than a single miracle drug.

Imatinib is currently the most popular therapy for chronic myeloid leukemia (CML). CML is a type of blood cancer that is most common among middle-aged adults and accounts for 15-20% of all cases of adult leukemia in the western world. Accumulation of cancer cells in the patient's blood causes infections, anemia, and other potentially life-threatening complications.

CML is associated with the abnormal fusion of a portion of chromosome 21 with a cell growth-promoting enzyme called ABL, which makes the enzyme perpetually active. Imatinib slows down the spread of cancer by blocking the enzyme's activity. But the drug doesn't work in everyone and resistance often develops, most likely because the drug only targets mature cells, leaving self-renewing cancer stem cells behind.

Now, Xiaoyan Jiang and a team of researchers from the British Columbia Cancer Agency in Vancouver and other institutions may have discovered what protects the stem cells from imatinib.

The team found that a protein called AHI-1, which has been found in leukemia cells in the past, is highly expressed in CML stem cells. When Zhou and colleagues blocked AHI-1 in cancer cells from imatinib-resistant CML patients, they restored the ability of the drug to kill the cells. The next step, says Jiang is finding a drug that blocks AHI-1, which could potentially be given in combination with imatinib in the future.




Leave a Reply.


         
    Let's Celebrate Life!



    GIPAP

    since 2003



    Pinoy Ako!!!

    Proudly Pinoy!



          Archives

    November 2009
    July 2009
    June 2009
    May 2009
    April 2009
    March 2009


         Categories

    All
    Crafts
    Dear God
    Life Story
    Life Tips
    News
    Poems
    Posters
    Quotes
    Stories




    Semptember is
    Childhood Cancer Awareness Month


    It is an opportunity to

    Honor the courage of kids/teens with cancer and their families
       

    Offer much-needed recognition and support to kids with cancer and their families It is a reminder for everyone...

    Children can have cancer. Metro Manila cancer registry records in three hospitals, show that eight kids/one very 3 hours, die everyday.
    Many more cases and deaths remain unreported

      
     
    Childhood cancer strikes randomly, unexpectedly, regularly, sparing no age group, socioeconomic status, ethnic group or geographic region. Children as young as a few months, barely able to talk and walk, can already have cancer
       

    Children can survive cancer, with early diagnosis and prompt, adequate treatment. In developed countries, childhood cancer survival rate is as high as 95%.
    In the Philippines, sadly,
    it is only 10to 30%.
    Of ten who are diagnosed, only two/three will most
     likely survive. They die because they are poor,
     unable to afford the high costs of medication and treatment


     It is a call to action:
    Work Together
    to help neighbors, classmates, and colleagues whose lives may be burdened by childhood cancer


    Working together we can help them FACE and BEAT Cancer. We can give them the greatest gift of all ---
    a chance to live fully --
    to have a future


    So please,
    GET INVOLVED.
    KIDS SHOULD NOT FIGHT CANCER ALONE.

    There are so many ways you can help.


    Post this message in your bulletin boards,
    in your churches, at school,
    at work, in your barangay halls/ community centers,
    in your blogs or home pages
       
    Pledge any amount to
    help buy medicines for kids with cancer. As little as
    P 250.00 will go a long
    way to save a life
       

    Let your church leaders, media friends and elected officials know. One child/teen die every three hours because they are too poor to afford the high cost of cancer treatment.

    Ask them to
    DO SOMETHING TO
    STOP THE DYING
     
      

    Sponsor a child for a minimum of P5,000 a month. You can do this with your family, group of friends or co-workers    

    Sponsor an event /
    Make CWFI your beneficiary
    in special events in your church, school or neighborhood
       

    Write an article,
    a story or a letter to the editor on the situation of
    kids with cancer –
    the forgotten, neglected children of our society
       

    Buy and/or sell
    CWFI love gifts
    (gold ribbon magnets,
    key chains, pins,
    eco friendly bags, t-shirts)
      

     
    Endorse CWFI to a
    possible sponsor.
     100% of funds raised go to treatment of poor kids
     with cancer
       

    Take time.
    Be a volunteer.
    Be a Cancer Warrior
       

    Help raise funds
    from others throw aways:
    old newspapers, used paper, toys, books etc.

       

    Request for your very own coin banks of hope
    (Alkansya nang Pag-Asa)
       

    Celebrate your special moments
    (birthdays, anniversaries, yearly employee events, school fairs)
    with kids with cancer.

    Moments of fun help bring some joy and relaxation in their pain wracked lives
       

    Make a donation to Cancer Warriors Foundation Metrobank Account Number: 7-168-50924-0



    RSS Feed


An organization consist of CML and GIST patients.